Therefore, the present study was undertaken to explore the roles of ATF3 and irisin in human CRC by determining serum and mRNA levels in subcutaneous and visceral white adipose tissues (sWAT and vWAT) of ATF3 and irisin among normal-weight (NW) and overweight/obese (OW/OB) CRC patients. Here, ATF3 is linked to colorectal carcinoma.