As illustrated in Figure 3, ATF3 and irisin could discriminate CRC patients from healthy controls with ROC curve areas of 0.745 (95% CI, 0.655–0.823, P < 0.01) and 0.656 (95% CI, 0.561–0.743, P < 0.01), respectively. The gene discussed is FNDC5; the disease is colorectal carcinoma.