Therefore, based on a largest sample capacity of 4,140 patients from 24 clinical trials at present, we conducted a comprehensive pooled analysis of gender differences, including the following aspects: risk of arrhythmic events, EPS status, family history of SCD, spontaneous type 1 ECG pattern, SCN5A mutation, diagnosis status, and documented AF status. The gene discussed is SCN5A; the disease is Schnyder corneal dystrophy.