For intestinal miRNAome, the immune-related pathways, including “ECM-receptor interaction”, “cell adhesion molecules,” and “apoptosis” were in the early and middle stages, “VEGF signaling pathway” and “cytokine-cytokine receptor interaction” were in both the middle and late stages, “NOD-like receptor signaling pathway” was only in the middle stages, with “RIG I-like receptor signaling pathway” and “herpes simplex infection” being in the late stages, were revealed (Figure 5). The gene discussed is VEGFA; the disease is herpes simplex infectious disease.