INS and Insulin resistance: In the 12th month of the follow-up, obese patients with pre-diabetics condition treated by metformin (group 1) vs. obese patients with pre-diabetic condition treated by placebo (group 2) experienced a significant reduction of heart rate (67 ± 8 vs. 71 ± 5, p <0.05), of WHR (0.79 ± 0.003 vs. 0.88 ± 0.005, p <0.05), with a reduction of glucose values (5.48 ± 0.12 vs. 6.68 ± 0.18 mmol/L, p <0.05), and an amelioration of insulin resistance (HOMA-IR 4.2 ± 0.35 vs. 5.0 ± 0.68, p <0.05; Insulin 22.7 ± 1.7 vs. 20.1 ± 1.5 μU/ml) Table 5.