At 12 months of follow-up, obese patients with pre-diabetic condition treated by placebo (group 2) vs. obese patients with normo-glycemic condition(group 3) had higher values of heart rate (71 ± 5 vs. 66 ± 7, p <0.05), of WHR (0.88 ± 0.005 vs. 0.81 ± 0.001 vs., p <0.05), of glucose values (6.68 ± 0.18 vs.5.32 ± 0.59 mmol/L, p <0.05), with insulin resistance (HOMA-IR 5.0 ± 0.68 vs. 4.1 ± 0.28, p <0.05; Insulin 20.1 ± 1.5 vs. 23.1 ± 1.6 μU/ml), and higher serum values of creatinine (99.4 ± 3.5 vs. 74.8 ± 1.8 mmol/L, p <0.05) Table 5. This evidence concerns the gene INS and Insulin resistance.