The novelty of this study is that, in patients with pre-diabetic condition vs. patients with normo-glycemic condition, the baseline hyperglycemic condition and the insulin resistance are linked to higher expression of serum inflammatory cytokines and nitrotyrosine, and to a lower expression of SIRT1 in the subcutaneous abdominal fat Figures 1–6, Tables 1–5. The gene discussed is SIRT1; the disease is Insulin resistance.