Previous studies by our group have shown the involvement of the glutathione (GSH) system, that becomes exhausted with a high activity of glutathione reductase (GR) and a diminished activity of Glutathione-S-transferase (GST) and glutathione peroxidase (GPX), as well as an increase in lipoperoxydation, which was associated with ONOO− increase (Zúñiga-Muñoz et al., 2017) in MS aortic tissue. This evidence concerns the gene HPGDS and myeloid sarcoma.