From the point of view of fascioliasis, the interest of this fibrinolytic system and the tPA mainly, but not only, relies on the multifunctional roles of plasmin in inflammation (Li, 2005; Syrovets et al., 2012; Lin and Hu, 2014) including central nervous system affection (Gur-Wahnon et al., 2013) and blood-brain barrier permeability (Yepes et al., 2003; Michalski et al., 2012; Niego et al., 2012; Jin et al., 2014; Niego and Medcalf, 2014; Marcos-Contreras et al., 2016; Suzuki et al., 2016) including neurological effects (Fanne et al., 2010; Dong et al., 2016). The gene discussed is PLG; the disease is fascioliasis.