Increased protein levels of Gal‐3 are correlated with the poor survival of various cancers, including leukaemia, lymphomas, breast cancer and thyroid cancer.6 Gal‐3 was overexpressed in RCC patients with distant metastasis.14 While chemokines and their receptors influence the initiation and progression of tumours in the tumour microenvironment, their role in the Gal‐3‐promoted CSC formation and drug resistance of RCC remains unclear.5 In this study, we found that Gal‐3 was highly expressed in the CSCs of RCC, as well as the clinical tissues of advanced RCC. Here, LGALS3 is linked to neoplasm.