Intracellular Gal‐3 interacts with RAS and β‐catenin to enhance cell transformation and proliferation.8, 9, 10 Furthermore, Gal‐3 augments tumour stem cell property and drug resistance through its interaction with β‐catenin.12 Several chemokine and chemokine receptor genes, such as CXCR4, CXCR7 and CCL5,19, 20 are the downstream genes of β‐catenin. Here, ACKR3 is linked to neoplasm.