CXCL12 and gastric cancer: SDF‐1 and IL‐8 can synergistically increase endothelial cell proliferation and migration, boosting the angiogenic pathway with IL‐8, predominantly induced in gastric cancer.35, 38, 64 The secretion of IL‐6, FAP, and IL‐8 by CAFs plays pivotal role in macrophage differentiation or M2 polarization resulting in an immunosuppressive microenvironment.36