CXCL12 and cancer: TNC belongs to an antiadhesive or adhesion‐modulating proteins that have been shown to interact with fibronectin and to promote the migratory activities of various cell types including fibroblasts, epithelial, and cancer cells.71 The elevated expression of IL‐6, IL‐8, and SDF‐1 mRNAs could be mediated by the increased deposition of TNC.