To determine the effects of bone marrow selective inactivation of PDZK1 on high fat diet induced atherosclerosis, low density lipoprotein receptor (ldlr) knockout (KO) mice were transplanted with bone marrow (BM) from either pdzk1 KO or corresponding wild type (wt) mice, allowed to recover for 4 weeks and then fed a high fat diet for a further 10 weeks. Here, LDLR is linked to atherosclerosis.