As an index for 18F-FMISO uptake, TMR showed positive correlation with tumor biological indicators including HIF-1α, Glut-1, Ki67, P53, and MVD (r = 0.92, 0.86, 0.89, 0.70, 0.81, p < 0.01) by Pearson correlation coefficient analysis. This evidence concerns the gene HIF1A and neoplasm.