As an index for 18F-FMISO uptake, TMR showed positive correlation with tumor biological indicators including HIF-1α, Glut-1, Ki67, P53, and MVD (r = 0.92, 0.86, 0.89, 0.70, 0.81, p < 0.01) by Pearson correlation coefficient analysis. The gene discussed is MKI67; the disease is neoplasm.