In the study of the hepatocellular carcinoma SMMC-7721 tumor-bearing mice, Huaier was found to significantly inhibit hypoxia inducible factor (HIF)-1 protein and vascular endothelial growth factor (VEGF) expression, reduce microvessel density [18], and inhibit macrophage-mediated angiogenesis [19]. This evidence concerns the gene VEGFA and hepatocellular carcinoma.