HMGB1 and head and neck squamous cell carcinoma: In addition, to evaluate the potentiality of HMGB1 as an early diagnostic marker for HNSCC, the correlation of HMGB1 expression in the tumor samples with clinical and pathologic factors in patients with HNSCC and healthy controls was estimated, and the sensitivity and specificity of HMGB1 marker were evaluated in the tissue and blood samples.