Table 2 presents the levels of HMGB1 expression in the tumor and normal tissue samples. The positive expression of HMGB1 in HNSCC tissues was demonstrated through brown staining in the cytoplasm or nuclei or both cytoplasm and nuclei. Figure 1 displays the results of HMGB1 expression in the tumor and normal tissues. This evidence concerns the gene HMGB1 and head and neck squamous cell carcinoma.