NFKB1 and noise induced hearing loss: In other research, curcumin has a protective effect against noise-induced hearing loss (NIHL), which is hypothesized to be through the inhibited the degradation of Ikβ in the cochlea and suppression formation of 4-hyroxynonenal (4-HNE) in the cochlea spiral ligament, which leads to suppression of the NFκβ signal (20).