However, a growing body of evidence has indicated that IL-2 is crucial for the development and function of regulatory T cells (Treg cells), which secrete effector cytokines, such as IL-10, to control and modulate the immunity to self, neoplasia, microorganisms, and grafts (Owen et al., 2013; Pérol & Piaggio, 2016). The gene discussed is IL10; the disease is neoplasm.