The revised criteria for SLE classification includes detection of antinuclear antibodies (ANA) and extractable nuclear antibodies (ENA)11 which mediate the disease and are associated with distinct SLE disease subsets and progression.12 13 Autoantibody production is influenced by, among other factors, human leucocyte antigen (HLA) haplotype,14 with the HLA haplotype believed to influence disease prevalence, for example, increased rates of SLE in African-Americans and more frequent detection of SLE in first-degree relatives15 16compared with unrelated people. The gene discussed is ENAH; the disease is systemic lupus erythematosus.