Based on our findings, despite pharmacological agents of NDRG2 modulators await to be clarified, genetic overexpression of photoreceptor NDRG2 based on cell-targeting techniques such as the aptamer-modified liposomes70,71 may represent a promising solution to prevent and rescue retinal degeneration, which is worth to be evaluated by further experiments. Here, NDRG2 is linked to retinal degeneration.