This inhibition of unfolded protein response by metformin has been already reported.37 In addition, the observed relationship between metformin and histone levels have been identified earlier.38 Furthermore, SiComPre 1.0 also suggests that metformin affects cell motility and the cytoskeleton, as shown in PC3 and DU145 prostate cancer cells.39 The predicted complexes responsible for this overlapping pattern can be matched to the chaperonin containing TCP1 complex, p97-Ufd1-Npl4-IP3 receptor complex, Smcb-Smcd-PW29 complex, Xin-Cdh2-Ctnnb1-Ctnnd1 complex, and Kif3-cadherin-catenin complex. The gene discussed is XIRP1; the disease is prostate cancer.