Moreover, it was reported to inhibit proliferation, chemotaxis, and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo [59], as well as vascular endothelial growth factor (VEGF)-induced vascular permeability [60], suggesting that it might ameliorate angiogenesis-related diseases, such as tumor metaplasia, rheumatoid arthritis, diabetic retinopathy, and age-related macular degeneration, acting as a novel angiogenesis inhibitor [59, 61, 62]. The gene discussed is VEGFA; the disease is diabetic retinopathy.