ERBB2 and cancer: According to Missiaglia and colleagues [28], microsatellite instable-high (MSI) and BRAF mutation were predominate among proximal (right-sided) tumours, while distal cancers (left-sided) were characterised by chromosome instable, high expression of epiregulin, and human epidermal growth factor receptor 2 (HER2) amplification [24, 29, 30].