TGFβ blockade is effective at inducing CD8 T cell influx (33, 34), and synergizes with radiation in other tumor types (35, 36); however whether blockade of TGFβ signaling in pancreatic tumors would synergize with radiation is unclear given that pancreatic cancer cells rely on TGFβ signaling to maintain radiosensitivity (37). The gene discussed is TGFB1; the disease is familial pancreatic carcinoma.