CD8A and familial pancreatic carcinoma: TGFβ blockade is effective at inducing CD8 T cell influx (33, 34), and synergizes with radiation in other tumor types (35, 36); however whether blockade of TGFβ signaling in pancreatic tumors would synergize with radiation is unclear given that pancreatic cancer cells rely on TGFβ signaling to maintain radiosensitivity (37).