Moreover, increased numbers of IFN-γ producing cells in TIL were observed after α-GalCer-pulsed APC administration, indicating that the systemic intravenous administration of α-GalCer-pulsed APCs led to local iNKT cell accumulation in the tumor microenvironment and induced immune responses by producing IFN-γ. The gene discussed is IFNG; the disease is neoplasm.