SYNE1 and neuromuscular junction disease: Finally, some emerging role of nesprin-1 in the formation of striated F-actin-based filaments (Packard et al., 2015) or in Drosophila, in the control of glutamate receptors density, specifically at the neuromuscular junction (Morel et al., 2014) suggests that SYNE1 mutations could be highlighted in other neuromuscular junction diseases.