For example, such alterations are more and more described for laminopathies with the hyperactivation of the ERK (extracellular signal-regulated kinase) pathway in cardiomyopathy caused by LMNA mutations (Chatzifrangkeskou et al., 2018) or the overexpression of SMAD6, an inhibitor of the BMP signaling pathways, as a cause of accelerated myogenic differentiation of LMNA mutated cells (Janin et al., 2018). The gene discussed is LMNA; the disease is cardiomyopathy.