SYNE1 and autosomal recessive ataxia, Beauce type: Mutations in SYNE1, coding for nesprin-1, have been reported to cause neurodegenerative diseases such as “Autosomal Recessive Cerebellar Ataxia type 1” (ARCA1), also called “Autosomal recessive ataxia, Beauce type” (Gros-Louis et al., 2007).