Our recent study (Su et al., 2014) found that Disrupted-In-Schizophrenia-1 (DISC1), one of robust gene-candidate associated with schizophrenia (Brandon and Sawa, 2011; Porteous et al., 2011) interacts with D2R through the third intracellular loop of D2R. This evidence concerns the gene DRD2 and schizophrenia.