Notably, pharmacological inhibitors of other DISC1 interacting proteins, such as GSK-3 (Lipina et al., 2011a) and PDE4B (Clapcote et al., 2007), also induced APD-like capacities in Disc1-L100P mice and dual inhibitor of GSK-3 and PDE7, VP1.15, elicited APDs features in amphetamine pharmacological model of schizophrenia (Lipina et al., 2013). Here, DISC1 is linked to schizophrenia.