TAT-peptide uncoupling DISC1 × D2R complex reversed hyperactivity and deficit of sensorimotor gaiting, induced by either amphetamine/apomorphine in rats or by genetic Disc1-L100P mutation in mice (Su et al., 2014), hence, eliciting APDs features in both pharmacological and genetic animal models of schizophrenia. Here, DISC1 is linked to schizophrenia.