Four significant Reactome pathways shared by AD and IS were immunoregulatory interactions between a lymphoid and a non-lymphoid cell [R-HSA-198933], synthesis of PIPs at the plasma membrane [R-HSA-1660499], PI metabolism [R-HSA-1483255] and cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding [R-HSA-6814122]. Here, FLVCR2 is linked to Alzheimer disease.