These genes belong to 12 established risk loci for AD (i.e., APOE/TOMM40/APOC1 locus; EXOC3L2/BLOC1S3/MARK4 locus; PVRL2; CR1; HLA-DRB5-DRB1 region; EPHA1; CLU; PICALM; ABCA7; CD33; MS4A locus; BIN1). The gene discussed is PICALM; the disease is Alzheimer disease.