Additionally, there is a significantly higher phosphorylation level of basal endothelial nitric oxide synthase (eNOS) at S1177 in type 2 diabetes mellitus (T2DM) patients, and the abnormal eNOS activation mediated by phosphorylation has been suggested to play a potential role in endothelial insulin resistance [13]. This evidence concerns the gene NOS3 and type 2 diabetes mellitus.