MTSS1 and Familial prostate cancer: For example, the ubiquitination of metastasis suppressor 1 (MTSS1), an important tumor suppressor, mediated by the skp1-cullin1-F-box beta-transducin repeat-containing protein (SCF β-TRCP) E3 ubiquitin ligase complex, is essential for regulating cell proliferation and migration in breast and prostate cancers [12].