Therefore, we conducted the present study to investigate the influences of two commonly used anesthetic methods, propofol/opioids-based TIVA and sevoflurane-based inhalational anesthesia, on the release of angiogenic factors including VEGF and transforming growth factor-β(TGF-β) which play a crucial role in tumor progression [16–18], and on the recurrence-free survival (RFS) and overall survival (OS) rates in the patients undergoing MRM or BCS. Here, TGFB1 is linked to neoplasm.