Of 12 identified genes in this prognostic model, three (COPS8, SUGCT and DUSP10) played a protective role in HCC patients, and by contrast the other nine (EIF5B, MNAT1, WASF1, EWSR1, POLR3C, RNF24, PCSK5, NRBP1 and CCDC88A) acted as risk factors for HCC. This evidence concerns the gene EIF5B and hepatocellular carcinoma.