RTG activates all neuronally expressed KCNQ isoforms (KCNQ2–5), with a preference for KCNQ3 (ref. 21), and in addition to epilepsy showed promise in treating disorders including anxiety, neuropathic pain, neurodegenerative disorders, cancer, inflammation, and ophthalmic diseases22–25. Here, KCNQ2 is linked to epilepsy.