NOTCH2 and B-cell chronic lymphocytic leukemia: Similar to our results from conditional Notch2-deficient murine BMSCs (Fig. 3f and Supplementary Data 1+2), CRIPSR/Cas9 deletion of Notch2 also down-regulated complement C1q messenger RNA (mRNA) expression in CLL-activated EL08-1D2 cells (Fig. 4i).