Up regulation of Bcl-2 family members is an important mechanism causing chemo resistance, and combined inhibition of Bcl-2, Bcl-xl and Bcl-w with the BH3-mimetic ABT-7374 successfully induced sensitization of chondrosarcoma cell lines of all different subtypes to the chemotherapeutic agents doxorubicin and cisplatin5–7. The gene discussed is BCL2; the disease is chondrosarcoma.