Bcl-xl was expressed in 101 out of 102 chondrosarcomas (35 were lost from the TMA) and the extent and intensity significantly correlated with histological grade in central chondrosarcoma (ACT vs. grade II: P = 0.0035, ACT vs. grade III: P = 0.0034) (Fig. 1b). This evidence concerns the gene BCL2L1 and chondrosarcoma.