Parkin (PARK2) is a 465-residues multifunctional E3 ubiquitin ligase comprising an N-terminal auto-inhibitory ubiquitin-like domain (Ubl), a unique Parkin-specific domain, two RING domains (RING0, RING1), an in between RING (IBR) domain, and a C-terminal RING domain (RING2) whose mutations are the most common known cause of autosomal recessive early-onset Parkinson’s disease (PD)18–21. Here, PRKN is linked to Parkinson disease.