PRKN and Parkinson disease: Our results indicate that Parkin controls the basal levels of the MCU regulator MICU1 and, since the MICU2 stability strictly depends on that of MICU110,11, Parkin, indirectly also controls MICU2 levels, possibly suggesting that PD-related loss of function mutations in Parkin gene may result in defective mitochondrial assembly of the MCU complex components that in turn could contribute to PD pathogenesis.