MYH14 and ocular melanoma: It had previously been suggested that the slowed motility could be due to increased force dependence of myosin detachment in the presence of the drug6,7,9, but a 10-fold increase in the distance parameter, d, corresponding to a greatly increased force sensitivity of detachment could not reproduce the observed suppression of the gliding velocity by OM in the in vitro motility assay (Supplementary Fig. 8, brown).