Importantly, the KU60019-mediated stimulus to GIC-mitosis in vivo was prolonged in time (Fig. 5C,D), since the significantly increased proliferative activity of GIC, as indicated by KI67 tumor staining, was detected 42 days (d108 of tumor development) after the last drug CED (d66 of tumor development) (Fig. 5C,D). This evidence concerns the gene MKI67 and neoplasm.