CAT and craniodiaphyseal dysplasia: The selective protection of HIF-1α against the CDD-induced suppression of peroxisomal fatty acid oxidation might help reduce the metabolic burden of excessive fatty acid oxidation in the mitochondria, resulting in decreased ROS production and the subsequent mitigation of ROS-induced disease progression toward steatohepatitis, as catalase enriched in peroxisome can efficiently reduce hydrogen peroxide produced in peroxisomal fatty acid oxidation.