TFAM and melanoma: Differential expression analysis between the two groups of melanoma cell lines showed 295 differently expressed genes (DEGs) (FDR < 0.05), from which 131 were down-regulated and 164 were up-regulated in TFAM down cell lines (Fig. 5A and Supplementary Table S2 - Tab DEGs WM melanoma cell lines), indicating clear gene expression differences between the groups.