In cancer and PAH, such glycolytic enzyme targets include Hexokinase, glucose 6 phosphate dehydrogenase (G6PD), phosphofructokinase 2/fructose bisphosphatase 3 (PFK2/PFKFP3), pyruvate kinase 2 (PKM2), lactate dehydrogenase, and pyruvate dehydrogenase kinase41. This evidence concerns the gene PFKFB3 and pulmonary arterial hypertension.