In assumption, increased oxLDL levels in the circulation and vascular endothelial cells could be captured by macrophages and dendritic cells, which are professional antigen-presenting cells, and as a result, MHC II-restricted ApoB100-derived peptide epitopes are presented to CD4+ T cells, leading to inflammatory immune responses that in turn contribute to the development of atherosclerosis. Here, APOB is linked to atherosclerosis.