RPS6KB1 and thyroid gland carcinoma: Here, we used Phospho-S6 and Phospho-p70S6K as readouts for mTORC1 activity and found a decrease of Phospho-S6 and Phospho-p70S6K levels in all JPH203-treated thyroid cancer cells which indicates that mTORC1 activity is affected (Fig. 3).