And the expression of ZIKV-ENV do not correlate with the XBP1 expression or its translocation into the nucleus, this suggested that ZIKV-ENV may not be responsible for induction of IRE1-XBP1 pathway or IRE1-XBP1 pathway activated in the infection state with the low expression level of ZIKV-ENV. The gene discussed is ERN1; the disease is infection.