The ratios of xbp1s/t-xbp1 between mock and ZIKV infection were 15.8-fold (24 hpi) and 32.6-fold (48 hpi) in CCF-STTG1 cells, and 3.1-fold (24 hpi) and 10.9-fold (48 hpi) in SK-N-SH cells (Fig. 5a,b). This evidence concerns the gene XBP1 and Zika virus infectious disease.