To investigate the biological role of these CNV-mRNA-protein correlated genes, which associated with the prognosis in CRC progression and liver metastasis, we established the CRC cell line SW480 to stably overexpress COL1A2 or BGN to perform the gain-of-function studies in vitro (Fig. 5c). The gene discussed is COL1A2; the disease is colorectal carcinoma.