Our results showed that 4 up-regulated genes (HSP90AB1, COL1A2, FABP5 and BGN), which located in CNV hotspots (located in 6p21.1, 7q21.3, 8q21.13 and Xq28, respectively) were associated with prognosis of CRC patients (Fig. 5a). Here, BGN is linked to colorectal carcinoma.