HSP90AB1 and colorectal carcinoma: Our results showed that 4 up-regulated genes (HSP90AB1, COL1A2, FABP5 and BGN), which located in CNV hotspots (located in 6p21.1, 7q21.3, 8q21.13 and Xq28, respectively) were associated with prognosis of CRC patients (Fig. 5a).