Even though infiltration of macrophages in brains of transgenic AD mice was already observed by others ([27], reviewed in [23]), the clear presence of Iba1+ cells lacking the microglia-specific marker TMEM119 (Iba1+/TMEM119−) located at sites of amyloid plaques in transgenic AD mouse brains is to our knowledge not yet reported. This evidence concerns the gene AIF1 and Alzheimer disease.