In line with this data, Guillot-Sestier et al. showed elevated IL10 signaling pathways in human AD brains and analysis of a transgenic AD mouse model with IL10 knockdown (APP/PS1 + IL10−/−) demonstrated mitigation of various AD characteristics and again promotes microglia amyloid-beta phagocytosis in these mice [97]. This evidence concerns the gene PSEN1 and Alzheimer disease.