Tumor size and Ki-67 expression at baseline were also independent predictors of pCR (P = 0.030, HR = 0.536 for T3, and HR = 0.430 for T4, T2 as reference; and P = 0.001, HR = 2.826 for high Ki67, low Ki-67 as reference, respectively). This evidence concerns the gene MKI67 and neoplasm.