MKI67 and neoplasm: Residual tumor size (P < 0.001), residual node involvement (P < 0.001), vascular invasion (P = 0.035), residual tumor Ki-67 (P = 0.001), sMMP-9 at surgery (P = 0.008), sMMP-9 change (P = 0.019) and hMMP-9 (P < 0.001) were significant predictors of DFS and were entered into the multivariate Cox regression model with forward selection.