Interestingly, 12 or 24 h after the monolayers were scratched, the sizes of the wounds were significantly smaller in 8505C cells transfected with HHIP-G516R than in cells transfected with the control vector or HHIP-WT (Figure 4C,D and Figure S5), indicating that the HHIP G516R mutation promotes thyroid cancer cell migration. This evidence concerns the gene HHIP and thyroid cancer.