PRKAA2 and atherosclerosis: In contrast, the protective effects of metformin on Drp1 expression, oxidative stress, and atherosclerosis were ablated when AMPK-α2 was knocked out in diabetic ApoE−/−/AMPK-α2−/− mice, suggesting metformin exerts antiatherosclerotic action in vivo via the AMPK-mediated blockage of Drp1-mediated mitochondrial fission [61].