AVPR2 and cancer: One of the studies that examined the inhibitory effects of MTF on mitochondrial complex I in cancer cells used the MTF-resistant Saccharomyces cerevisiae NADH dehydrogenase (Ndi1) that overexpressed in cell culture and in xenograft tumors in mice had no inhibitory effects on cancer cell growth under MTF treatment compared to controls showing impaired proliferation [17].