An expression profiling study in estrogen receptor positive MCF-7 breast cancer cells demonstrated that the antiproliferative effect of MTF is mainly a result of translational suppression of mRNAs of cell cycle regulators and tumor promoters, such as cyclin E2 (CCNE2) and ornithine decarboxylase 1 (ODC1), that are regulated via the mTORC1/4EBP protein pathway [71]. The gene discussed is CCNE2; the disease is breast cancer.