PRKAA1 and ovarian cancer: In ovarian cancer under normoglycemic levels (5.5 mM), MTF was more sensitive than under hyperglycemic levels (25 mM) to modify epigenetic profiles via AMPK activation, as indicated by repressed expression of histone H3 lysine 27 trimethylation (H3K27me3) and of components of polycomb repressor complex 2 (PRC2) [93].