Specific proteins in this group which have known roles in breast cancer include fibroblast growth factor receptor 2 (FGFR2) [11], filamin A (FLNA) [12,13], forkhead box A1 (FOXA1) [14], integrin subunit α5 (ITGA5) [15], intercellular adhesion molecule 1 (ICAM1) [16], interleukin 1β (IL1B) [17], interleukin 8 (CXCL8) [18], protein tyrosine kinase 6 (PTK6) [19], transcription factor SOX-9 [20], transforming growth factor β1 (TGFB1) [21], and Wnt-5a [22]. The gene discussed is PTK6; the disease is breast cancer.