In an attempt to increase the selectivity of Doxorubicin conjugates towards tumor vasculatures, Ryppa and group have reported on a matrix metalloproteinase-2/9 (MMP-2/MMP-9) cleavable conjugate of a divalent RGD peptidomimetic E-[c(RGDfK)2] [36]. Here, MMP2 is linked to neoplasm.