As investigated by Jiang and coworkers, recombinant mutated human TNF-α (RGD-rmhTNF-α) showed ability to bind αvβ3 integrin in vitro, enhanced intratumoral uptake of Doxorubicin via increased permeability into tumor blood-vessels and synergistic anti-tumor efficacy with Doxorubicin in tumor xenograft models [51]. This evidence concerns the gene TNF and neoplasm.