The triad of Arg-1,Hep-1, and glypican-3 has been recommended as the most effective method ofdetermining metastatic carcinoma HCC, with Arg-1 being the most specificmarker.12 Mandible andadrenal gland samples were positive for Hep-Par-1 and Arg-1, supporting the hepatoidnature of these lesions. The gene discussed is GPC3; the disease is hepatocellular carcinoma.