Traditional risk factors with a high/intermediate level of supporting evidencefor FN are extensive prior chemotherapy; ≥ 85% relative intensity; ageolder than 65 years; poor performance status; low albumin/high lactatedehydrogenase levels; comorbidities such as pulmonary, cardiovascular, and liverdisease; and diabetes mellitus.9-12 Primaryprophylaxis was not used in all the included studies (median, 36.9%; range, 0%to 100%). This evidence concerns the gene ALB and diabetes mellitus.