The exact mechanism of how the hypomethylated state regulates pathways involved in PD-L1 expression in melanoma needs to be further investigated, but constitutive expression of PD-L1 in melanoma cells may identify melanomas that have endogenous activation of IFN signaling pathways, analogous to effects of treatment with inhibitors of DNMT enzymes. This evidence concerns the gene DNMT1 and melanoma.