Moreover, the hypomethylation phenotype was associated with the up-regulation of genes responsible for generating endogenous immune responses in cancer cells treated with DNMTi, such as several type I interferon-stimulated, viral mimicry-related genes (IFI44, IFI27, OASL, IL29) and genes that are upstream of the type I interferon pathway (IFNB1, IRF7) in PD-L1CON cell lines (Chiappinelli et al., 2015, Liu et al., 2016). This evidence concerns the gene IFI27 and cancer.