The hypomethylated state of the PD-L1CON lines was possibly associated with the up-regulation of global mRNA expression in DEGs, which is conceptually similar to the up-regulation of gene expression upon reduction of DNA methylation levels following DNA methyl transferase (DNMT) inhibitor treatment (DNMTi), as reported in breast, ovarian, and colorectal cancer cell lines (Li et al., 2014). Here, DNMT1 is linked to colorectal cancer.