The two CpGs in the CD274 promoter were essentially unmethylated (<5% mean methylation) in both melanoma groups, whereas the two CpGs in the 5′UTR showed a loss of methylation (13% for cg15837913 and 16% for cg19724470) in group 2 (representative of constitutive melanoma) compared with group 1 (inducible melanoma, Figures S9A–S9E). The gene discussed is CD274; the disease is melanoma.